Search results for "Chemical carcinogens"
showing 4 items of 4 documents
Orthotopic Mouse Models of Urothelial Cancer
2017
Orthotopic mouse models of urothelial cancer are essential for testing novel therapies and molecular manipulations of cell lines in vivo. These models are either established by orthotopic inoculation of human (xenograft models) or murine tumor cells (syngeneic models) in immunocompromised or immune competent mice. Current techniques rely on inoculation by intravesical instillation or direct injection into the bladder wall. Alternative models include the induction of murine bladder tumors by chemical carcinogens (BBN) or genetic engineering (GEM).
Antioxidants and carcinogen metabolism
1982
Abstract Supplementation of diet with synthetic antioxidants has been shown to protect animals against a broad spectrum of chemical carcinogens. Some interest has been expressed in the use of these food additives as possible prophylactic agents. However, such considerations appear premature in view of the fact that the protective mechanism has not yet been elucidated. The present communication reviews the effect of antioxidants on carcinogen-metabolizing enzymes, one of the major candidates in the interpretation of the protective antioxidant action.